abstract：:The alterations, visible by light and electron microscopy, in the distal airway cells of Syrian golden hamsters were analyzed at several time intervals, from 6 hr to 4 weeks, after a single subcutaneous injection (120 mg/kg body wt) of 4-nitroquinoline 1-oxide (4NQO), a potent carcinogen. 4NQO induced injurious effect...

journal_title：Experimental and molecular pathology

authors： Ito T

更新日期：1985-04-01 00:00:00

abstract：:The effect of hypertension, hyperlipidemia, and the combination of both on acute and chronic myocardial ischemia were evaluated in a total of 30 male rabbits. After preliminary hypertension and/or hyperlipidemic load by loading of the abdominal aorta and/or cholesterol feeding, acute ischemia was produced by clipping ...

journal_title：Experimental and molecular pathology

authors： Kuwao S,Kubo K,Kishimoto H,Mori N,Nishiyama Y

更新日期：1985-04-01 00:00:00

abstract：:In a previous study the authors demonstrated monotypic foci, all of timidus type, in the atherosclerotic lesions and normal aortic tissue of glucose-6-phosphate dehydrogenase (G-6-PD) mosaic hares fed 25-hydroxycholesterol or triol in addition to a high-cholesterol diet. Other hares fed the high-cholesterol diet witho...

journal_title：Experimental and molecular pathology

authors： Lee KT,Janakidevi K,Kroms M,Schmee J,Thomas WA

更新日期：1985-02-01 00:00:00

abstract：:The effects of chronic treatment with isoproterenol, reserpine, prenalterol, and terbutaline on rat parotid gland were investigated by electron microscopy and X-ray microanalysis. Chronic isoproterenol treatment induced lower potassium and calcium concentrations in the acinar cells. The cells were enlarged and contain...

journal_title：Experimental and molecular pathology

authors： Müller RM,Roomans GM

更新日期：1984-12-01 00:00:00

abstract：:Sprague Dawley male rats (200-220 g) were subjected to a long-term treatment with low doses of catecholamines in an attempt to assess the effect of the adrenergic stimulation on ventricular weights, hemodynamics, and hydroxyproline content in the myocardium. Data are presented indicating that both exogenous catecholam...

journal_title：Experimental and molecular pathology

authors： Genovese A,Chiariello M,Bozzaotre M,Latte S,De Alfieri W,Condorelli M

更新日期：1984-12-01 00:00:00

abstract：:Plasma fibronectin modulates reticuloendothelial (RE) phagocytosis of cellular and tissue debris, fibrin microaggregates, and gelatin-coated particulates. An antigenically related, but more insoluble form of fibronectin is found in various tissues and suspected to play a role in vascular permeability, cell adhesion, a...

journal_title：Experimental and molecular pathology

authors： Saba TM,Cho E,Blumenstock FA

更新日期：1984-08-01 00:00:00

abstract：:Minoxidil, a vasodilating antihypertensive drug, was given orally at 10 mg/kg daily for 2 days to twelve 25- to 35-kg miniature pigs. Twelve control pigs were also studied. Minoxidil-treated pigs had tachycardia and hypotension and were killed 24 hr after the second dose. Gross examination showed diffuse hemorrhage in...

journal_title：Experimental and molecular pathology

authors： Van Vleet JF,Herman EH,Ferrans VJ

更新日期：1984-08-01 00:00:00

abstract：:The pathogenesis of skeletal muscle necrosis induced by crude Bothrops asper venom and isolated myotoxic phospholipase was studied using light and electron microscopy. White mice were injected intramuscularly with a dose of 2.5 micrograms/g and tissue samples were taken at 30 min and 1, 3, 6, 12, 24, and 48 hr. Toxin-...

journal_title：Experimental and molecular pathology

authors： Gutiérrez JM,Ownby CL,Odell GV

更新日期：1984-06-01 00:00:00

abstract：:Unique alpha-cell crystals, a herpes-like virus, islet amyloidosis, and immunohistochemical reactions of islets are compared in the rodent, Octodon degus, in animals with ordinary and high circulating glucose levels. Results suggest that crystals, virus, and amyloid are independent of blood sugar and bear no obvious r...

journal_title：Experimental and molecular pathology

authors： Spear GS,Caple MV,Sutherland LR

更新日期：1984-06-01 00:00:00

abstract：:The pathophysiological biology of human hypertrophic scar was examined in a long-term organ culture system. Fresh full-thickness, thin slices of scar were placed in petri dishes. Tissue was successfully maintained for 2 weeks in an environment made up of CMRL-1066 medium, fetal bovine serum, insulin, and hydrocortison...

journal_title：Experimental and molecular pathology

authors： Ehrlich HP,Buttle DJ

更新日期：1984-04-01 00:00:00

abstract：:The testicular effects of daily oral dosing with two glycol ethers--either ethylene glycol monomethyl ether (EGM) or monoethyl ether (EGE) were studied in the prepubertal rat by histological examination of the testes. Over the 11-day dosing period studied, EGM was found to produce testicular damage at dose levels of a...

journal_title：Experimental and molecular pathology

authors： Creasy DM,Foster PM

更新日期：1984-04-01 00:00:00

abstract：:The glycosaminoglycan (GAG) contents of hypertrophic scars, normal scars, and human skin from cadavers of matched ages were compared. Cellulose acetate electrophoresis, chondroitinase digestions, and reaction product and infrared analyses were used to characterize the component GAGs. DEAE-cellulose chromatography was ...

journal_title：Experimental and molecular pathology

authors： Donoff RB,Swann DA,Schweidt SH

更新日期：1984-02-01 00:00:00

abstract：:Subacute (2 week) oral or intravenous administration of DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), caused diarrhea and frequent emesis as early as 4 to 5 days in dogs (dose greater than or equal to 200 mg/kg/day). Diarrhea also occurred in monkeys after 1 week ...

journal_title：Experimental and molecular pathology

authors： Yarrington JT,Sprinkle DJ,Loudy DE,Diekema KA,McCann PP,Gibson JP

更新日期：1983-12-01 00:00:00

abstract：:Ten cases of myopathy caused by glycogen storage diseases of type II, III, and V, and phosphorylase b kinase deficiency are reported. So-called "abnormal lysosomes" or glycogenosomes which contain abundant glycogen were found in cases of type II, and in some numbers, in cases of type III, and in one case of phosphoryl...

journal_title：Experimental and molecular pathology

authors： Iwamasa T,Fukuda S,Tokumitsu S,Ninomiya N,Matsuda I,Osame M

更新日期：1983-06-01 00:00:00

abstract：:Selected estimates of lipid peroxidation were analyzed in mouse quadriceps femoris muscle immediately after submaximal prolonged (9 hr) and exhaustive maximal running (2-3 hr), and at intervals 1-10 days afterward during the exercise-induced myopathy. Immediately after the two types of exertion no significant changes ...

journal_title：Experimental and molecular pathology

authors： Salminen A,Vihko V

更新日期：1983-06-01 00:00:00

abstract：:The autoimmune manifestations of MRL-+/+ (MRL/n) and MRL/Mp-lpr/lpr (MRL/l) murine models of systemic lupus erythematosus (SLE) were successfully reversed following total lymphoid irradiation (TLI) therapy consisting of 8-12 daily fractions of 200 rad. Following radiotherapy the characteristic lymphadenopathy of MRL/l...

journal_title：Experimental and molecular pathology

authors： Moscovitch M,Rosenmann E,Neeman Z,Slavin S

更新日期：1983-02-01 00:00:00

abstract：:Quartz dust cytotoxicity was studied in starch-stimulated and nonstimulated mouse peritoneal macrophage cultures in vitro. Morphological changes, release of lactate dehydrogenase (LDH) into the culture medium, and lactate production were used as parameters of cell damage. Phagocytosis of quartz dust by macrophages inc...

journal_title：Experimental and molecular pathology

authors： Kaw JL

更新日期：1983-02-01 00:00:00

abstract：:Bezafibrate and clofibrate reduce the quantity of esterified cholesterol, decrease the incorporation of 14C-labeled oleic acid into cholesterol ester and inhibit acyl coenzyme A cholesterol acyltransferase activity in rabbit peritoneal macrophages stimulated with acetylated low density lipoprotein. In all cases, the e...

journal_title：Experimental and molecular pathology

authors： Hudson K,Mojumder S,Day AJ

更新日期：1983-02-01 00:00:00